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Telaglenastat - Synhale Therapeutics

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Drug Profile

Telaglenastat - Synhale Therapeutics

Alternative Names: CB 839

Latest Information Update: 06 Nov 2025

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At a glance

  • Originator Calithera Biosciences
  • Developer Calithera Biosciences; Case Western Reserve University; Cornerstone Pharmaceuticals Inc; M. D. Anderson Cancer Center; National Cancer Institute (USA); Pfizer; Synhale Therapeutics
  • Class Acetamides; Antineoplastics; Ethers; Fluorinated hydrocarbons; Pyridazines; Pyridines; Small molecules; Thiadiazoles
  • Mechanism of Action Glutaminase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Pulmonary hypertension
  • Discontinued Astrocytoma; Cancer; Chronic obstructive pulmonary disease; Colorectal cancer; Glioma; Haematological malignancies; Leukaemia; Malignant melanoma; Multiple myeloma; Myelodysplastic syndromes; Non-small cell lung cancer; Pancreatic cancer; Renal cell carcinoma; Solid tumours; Triple negative breast cancer

Most Recent Events

  • 03 Nov 2025 Synhale Theraputics in collaboration with University of Pittsburgh plans a phase I/II trial for Pulmonary hypertension in USA, in November 2025 (PO) (NCT07223528)
  • 22 Oct 2025 Updated efficacy and adverse events data from the trial phase II Basket trial in Cancer at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics 2025
  • 01 May 2025 Preclinical trials in Pulmonary hypertension in USA (PO), before May 2025

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