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Telaglenastat - Cornerstone Pharmaceuticals

Drug Profile

Telaglenastat - Cornerstone Pharmaceuticals

Alternative Names: CB 839

Latest Information Update: 12 May 2025

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At a glance

  • Originator Calithera Biosciences
  • Developer Calithera Biosciences; Case Western Reserve University; Cornerstone Pharmaceuticals Inc; M. D. Anderson Cancer Center; National Cancer Institute (USA); Pfizer; Synhale Therapeutics
  • Class Acetamides; Antineoplastics; Ethers; Fluorinated hydrocarbons; Pyridazines; Pyridines; Small molecules; Thiadiazoles
  • Mechanism of Action Glutaminase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Clinical Phase Unknown Pulmonary hypertension
  • Preclinical Cancer; Chronic obstructive pulmonary disease
  • Discontinued Colorectal cancer; Glioma; Haematological malignancies; Leukaemia; Malignant melanoma; Multiple myeloma; Myelodysplastic syndromes; Non-small cell lung cancer; Pancreatic cancer; Renal cell carcinoma; Solid tumours; Triple negative breast cancer

Most Recent Events

  • 01 May 2025 Synhale Therapeutics acquires Telaglenastat from Cornerstone Pharmaceuticals
  • 01 May 2025 Clinical trials in Pulmonary hypertension (PO)
  • 01 May 2025 Synhale Terapeutics plans a phase II trial for Pulmonary hypertension

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