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Lorlatinib - Pfizer

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Drug Profile

Lorlatinib - Pfizer

Alternative Names: [14C]Lorlatinib; Denlorlatinib - Pfizer; LORBRENA; LORVIQUA; Lorviqua; PF-06463922; PF-6463922

Latest Information Update: 28 Jul 2026

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At a glance

  • Originator Pfizer
  • Developer CStone Pharmaceuticals; New Approaches to Neuroblastoma Therapy Consortium; Pfizer; The EVAN Foundation; University of Southern California
  • Class Antineoplastics; Aza compounds; Benzoxazines; Nitriles; Pyrazoles; Pyridines; Small molecules
  • Mechanism of Action Anaplastic lymphoma kinase inhibitors; ROS1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Non-small cell lung cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Non-small cell lung cancer
  • No development reported Neuroblastoma

Most Recent Events

  • 28 Jul 2026 No recent reports of development identified for phase-I development in Neuroblastoma(Combination therapy, In adolescents, In children, In the elderly, In infants, Second-line therapy or greater, In adults) in Canada (PO, Tablet)
  • 28 Jul 2026 No recent reports of development identified for phase-I development in Neuroblastoma(Combination therapy, In adolescents, In children, In the elderly, In infants, Second-line therapy or greater, In adults) in France (PO, Tablet)
  • 28 Jul 2026 No recent reports of development identified for phase-I development in Neuroblastoma(Combination therapy, In adolescents, In children, In the elderly, In infants, Second-line therapy or greater, In adults) in United Kingdom (PO, Tablet)

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