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Lorlatinib - Pfizer

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Drug Profile

Lorlatinib - Pfizer

Alternative Names: [14C]Lorlatinib; LORBRENA; LORVIQUA; Lorviqua; PF-06463922; PF-6463922

Latest Information Update: 06 Jun 2024

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At a glance

  • Originator Pfizer
  • Developer CStone Pharmaceuticals; New Approaches to Neuroblastoma Therapy Consortium; Pfizer; The EVAN Foundation; University of Southern California
  • Class Antineoplastics; Aza compounds; Benzoxazines; Nitriles; Pyrazoles; Pyridines; Small molecules
  • Mechanism of Action Anaplastic lymphoma kinase inhibitors; ROS1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Non-small cell lung cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Non-small cell lung cancer
  • Phase I Neuroblastoma

Most Recent Events

  • 31 May 2024 Updated efficacy and adverse event data from the phase III CROWN trial in Non-small cell lung cancer released by Pfizer
  • 13 Dec 2023 SCRI Development Innovations in collaboration with Pfizer withdraws a phase II trial prior to enrollment in Non-small cell lung cancer (Late-stage disease, Second-line therpay or greater) in USA due to pharmaceutical funding partners decision (NCT05948462)
  • 09 Dec 2023 Efficacy and adverse event data from phase II trial in Lymphoma presented at the 65th American Society of Hematology Annual Meeting and Exposition (ASH-Hem-2023)
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