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Alternative Names:
[14C]Lorlatinib; LORBRENA; LORVIQUA; Lorviqua; PF-06463922; PF-6463922
Latest Information Update: 14 Jan 2023
Price :
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At a glance
Originator
Pfizer
Developer
CStone Pharmaceuticals; New Approaches to Neuroblastoma Therapy Consortium; Pfizer; The EVAN Foundation; University of Southern California
Class
Antineoplastics; Aza compounds; Benzoxazines; Nitriles; Pyrazoles; Pyridines; Small molecules
Mechanism of Action
Anaplastic lymphoma kinase inhibitors; ROS1 protein inhibitors
Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
Yes
-
Non-small cell lung cancer
New Molecular Entity
Yes
Highest Development Phases
Marketed
Non-small cell lung cancer
Phase I
Neuroblastoma
Most Recent Events
05 Nov 2022
Lorlatinib is still in phase I trials for Neuroblastoma in USA (NCT03107988)
27 Oct 2022
Updated efficacy and safety data from the phase III CROWN trial in Non-small cell lung cancer presented at the 47th European Society for Medical Oncology Congress(ESMO-2022)
09 Sep 2022
Efficacy and adverse events data from the phase III CROWN trial in in Non-small cell lung cancer presented at the 47th European Society for Medical Oncology Congress (ESMO-2022)
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