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Varegacestat - Immunome

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Drug Profile

Varegacestat - Immunome

Alternative Names: AL-102; BMS 986115; WHG-626

Latest Information Update: 25 Nov 2024

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At a glance

  • Originator Bristol-Myers Squibb
  • Developer Ayala Pharmaceuticals; Bristol-Myers Squibb; Novartis
  • Class Amides; Antineoplastics; Benzene derivatives; Benzodiazepines; Fluorinated hydrocarbons; Small molecules
  • Mechanism of Action Amyloid precursor protein secretase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Solid tumours
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III Fibroma
  • No development reported Haematological malignancies; Multiple myeloma; Solid tumours

Most Recent Events

  • 11 Nov 2024 Immunome initiates enrolment in a phase-I trial (In volunteers) in USA (Unspecified), (NCT06677996)
  • 07 Nov 2024 Immunome plans to initiate a phase I trial in healthy volunteers in the US (NCT06677996)
  • 28 May 2024 No recent reports of development identified for phase-I development in Multiple-myeloma(Combination therapy, Second-line therapy or greater) in Unknown (PO)

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