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Varegacestat - Immunome

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Drug Profile

Varegacestat - Immunome

Alternative Names: AL-102; BMS 986115; WHG-626

Latest Information Update: 18 Dec 2025

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At a glance

  • Originator Bristol-Myers Squibb
  • Developer Ayala Pharmaceuticals; Bristol-Myers Squibb; Novartis
  • Class Amides; Antineoplastics; Benzene derivatives; Benzodiazepines; Fluorinated hydrocarbons; Small molecules
  • Mechanism of Action Amyloid precursor protein secretase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Unspecified; Solid tumours
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III Fibroma
  • No development reported Haematological malignancies; Multiple myeloma; Solid tumours

Most Recent Events

  • 15 Dec 2025 Immunome announces intention to submit NDA to US FDA for Desmoid tumours in Q2 of 2026
  • 15 Dec 2025 Efficacy and adverse events data from a phase II/III RINGSIDE trial in Desmoid tumours released by Immunome
  • 31 Jul 2025 Varegacestat - Immunome receives Orphan Drug status in European Union

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