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Varegacestat - Immunome

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Drug Profile

Varegacestat - Immunome

Alternative Names: AL-102; BMS 986115; WHG-626

Latest Information Update: 13 Aug 2025

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At a glance

  • Originator Bristol-Myers Squibb
  • Developer Ayala Pharmaceuticals; Bristol-Myers Squibb; Novartis
  • Class Amides; Antineoplastics; Benzene derivatives; Benzodiazepines; Fluorinated hydrocarbons; Small molecules
  • Mechanism of Action Amyloid precursor protein secretase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Unspecified; Solid tumours
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III Fibroma
  • No development reported Haematological malignancies; Multiple myeloma; Solid tumours

Most Recent Events

  • 31 Jul 2025 Varegacestat - Immunome receives Orphan Drug status in European Union
  • 30 May 2025 Efficacy data from the phase II/III RINGSIDE trial in Fibroma presented at the 61st Annual Meeting of the American Society of Clinical Oncology (ASCO-2025)
  • 07 May 2025 Immunome completes phase-I trial (In volunteers) in USA (PO) (NCT06677996)

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