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Varegacestat - Immunome

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Drug Profile

Varegacestat - Immunome

Alternative Names: AL-102; BMS 986115; WHG-626

Latest Information Update: 30 May 2025

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At a glance

  • Originator Bristol-Myers Squibb
  • Developer Ayala Pharmaceuticals; Bristol-Myers Squibb; Novartis
  • Class Amides; Antineoplastics; Benzene derivatives; Benzodiazepines; Fluorinated hydrocarbons; Small molecules
  • Mechanism of Action Amyloid precursor protein secretase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Solid tumours
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III Fibroma
  • No development reported Haematological malignancies; Multiple myeloma; Solid tumours

Most Recent Events

  • 07 May 2025 Immunome completes phase-I trial (In volunteers) in USA (PO) (NCT06677996)
  • 07 Mar 2025 Immunome initiates a phase I trial (In volunteers) in USA (PO) (NCT06841315)
  • 03 Mar 2025 Immunome initiates a phase-I trial (In volunteers) in USA (PO), (NCT06855264)

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