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Fenebrutinib - Genentech

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Drug Profile

Fenebrutinib - Genentech

Alternative Names: GDC-0853; RG-7845; RO-7010939

Latest Information Update: 04 May 2026

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At a glance

  • Originator Genentech
  • Developer Chugai Pharmaceutical; Genentech
  • Class Antineoplastics; Antirheumatics; Piperazines; Pyrazines; Pyridines; Skin disorder therapies; Small molecules
  • Mechanism of Action Agammaglobulinaemia tyrosine kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Multiple sclerosis
  • No development reported Autoimmune disorders
  • Discontinued Chronic lymphocytic leukaemia; Chronic urticaria; Non-Hodgkin's lymphoma; Rheumatoid arthritis; Systemic lupus erythematosus

Most Recent Events

  • 23 Apr 2026 Efficacy and adverse event data from the phase III FENhance 1 trial and FENhance 2 trial in Multiple sclerosis released by Roche
  • 06 Mar 2026 Adverse events and pharmacokinetics data from a phase-I trial in Multiple sclerosis presented at the 127th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics
  • 02 Mar 2026 Efficacy and safety data from a phase III FENhance trial in Multiple sclerosis released by Genentech

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