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Fenebrutinib - Genentech

Drug Profile

Fenebrutinib - Genentech

Alternative Names: GDC-0853; RG 7845; RO 7010939

Latest Information Update: 03 Dec 2019

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At a glance

  • Originator Genentech
  • Developer Chugai Pharmaceutical; Genentech
  • Class Antineoplastics; Antirheumatics; Piperazines; Pyrazines; Pyridines; Small molecules
  • Mechanism of Action Agammaglobulinaemia tyrosine kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Rheumatoid arthritis; Systemic lupus erythematosus; Urticaria
  • No development reported Autoimmune disorders
  • Discontinued Chronic lymphocytic leukaemia; Non-Hodgkin's lymphoma

Most Recent Events

  • 26 Nov 2019 Genentech terminates Phase-II clinical trials in Urticaria (Treatment-resistant) in Canada, Germany and USA (PO) (NCT03693625)
  • 21 Nov 2019 Genentech terminates Phase-II clinical trials in Urticaria (Treatment-resistant) in Canada, Germany and USA (PO) (NCT03137069)
  • 17 Jul 2019 Genentech completes an extension phase II trial for Rheumatoid arthritis (Adjunctive treatment, Treatment-experienced) in USA, Argentina, Bulgaria, Brazil, Colombia, Mexico, Poland, Russia, Serbia and Ukraine (PO, Tablet) (NCT02983227)
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