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Bepirovirsen - GSK

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Drug Profile

Bepirovirsen - GSK

Alternative Names: 3228836; Bepirovirsen sodium; GSK'836; GSK-4388067; GSK-4388067A; GSK3228836; GSK3228836A; GSK3228836B; IONIS-HBVRx; ISIS 505358; ISIS-GSK3Rx; ISIS-HBVRx

Latest Information Update: 17 Sep 2025

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At a glance

  • Originator Isis Pharmaceuticals
  • Developer GSK; Ionis Pharmaceuticals
  • Class Antisense oligonucleotides; Antivirals
  • Mechanism of Action Gene silencing; Hepatitis B surface antigen expression inhibitors; Toll-like receptor 8 modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Hepatitis B

Most Recent Events

  • 16 Sep 2025 GlaxoSmithKline plans a phase I B-Kind pharmacokinetics trial for Hepatitis B (In volunteers, In adults, In the elderly) in September 2025 (NCT07168356)
  • 28 May 2025 Pharmacokinetics and pharmacodynamics data from a phase I trial in Hepatitis-B presented at the 126th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT-2025)
  • 07 May 2025 Pharmacokinetics and adverse event data from the phase I relative bioavailability trial in healthy volunteers presented at the European Association for the Study of the Liver Congress 2025 (EASL-2025)

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