Drug Profile

Ceralasertib - AstraZeneca/University of Pennsylvania

Alternative Names: AZD 6738

Latest Information Update: 25 Sep 2025

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At a glance

Originator AstraZeneca; University of Pennsylvania
Developer Acerta Pharma; AstraZeneca; Dana-Farber Cancer Institute; Gustave Roussy; National Cancer Institute (France); Samsung Medical Center; University of California at San Francisco; University of Pennsylvania
Class Antineoplastics; Cyclopropanes; Imines; Ketones; Morpholines; Organic sulfur compounds; Pyridines; Pyrimidines; Pyrroles; Small molecules
Mechanism of Action ATR protein inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Phase III Non-small cell lung cancer
Phase II Cholangiocarcinoma; Gynaecological cancer; Malignant melanoma; Osteosarcoma; Ovarian cancer; Pancreatic cancer; Prostate cancer; Small cell lung cancer; Solid tumours; Triple negative breast cancer
Phase I/II Chronic lymphocytic leukaemia
Phase I Chronic myelomonocytic leukaemia; Myelodysplastic syndromes
Preclinical Diffuse large B cell lymphoma; Type 1 diabetes mellitus
Discontinued Haematological malignancies; Non-Hodgkin's lymphoma; Squamous cell cancer

25 Sep 2025 3909969 - Kdm and clinical data added
30 May 2025 Efficacy and adverse events data from phase II clinical trials in Osteosarcoma presented at the 61^st Annual Meeting of the American Society of Clinical Oncology (ASCO-2025)
30 May 2025 Efficacy and adverse events data from the phase II NCI 10222 trial in Solid tumours presented at the 61^st Annual Meeting of the American Society of Clinical Oncology (ASCO-2025)

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