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Axicabtagene ciloleucel - Kite Pharma

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Drug Profile

Axicabtagene ciloleucel - Kite Pharma

Alternative Names: Anti-CD19-CAR-lentiviral-vector-transduced-autologous-T-cells-Kite-Pharma; Anti-CD19-CAR-PBL-Kite-Pharma/NCI; Anti-CD19-CAR-T-cell-therapy-Kite-Pharma/NCI; Anti-CD19-CAR-transduced-T-cells-Kite-Pharma/NCI; Anti-CD19-chimeric-antigen-receptor-lentiviral-vector-transduced-autologous-T-cells-Kite-Pharma; Anti-CD19-chimeric-antigen-receptor-peripheral-blood-lymphocytes-Kite-Pharma; Anti-CD19-chimeric-antigen-receptor-T-cells-Kite-Pharma/NCI; Anti-CD19-chimeric-antigen-receptor-transduced-T-cells-Kite-Pharma/NCI; anti-human CD19 CAR-T cell injection; Axi-cel®; Ejilunsai injection; FKC 876; KTE-C19; KTE-C19 CAR; YESCARTA; Yescarta; Yi Kai Da; YIKAIDA

Latest Information Update: 12 Dec 2024

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At a glance

  • Originator Cabaret Biotech
  • Developer Daiichi Sankyo Inc; Genentech; Gilead Sciences K.K.; H. Lee Moffitt Cancer Center and Research Institute; Kite Pharma; Kite Pharma - Fosun Pharma (JV)
  • Class Antineoplastics; CAR-T cell therapies; Gene therapies; Immunotherapies
  • Mechanism of Action Immunologic cytotoxicity; T lymphocyte replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Diffuse large B cell lymphoma; Chronic lymphocytic leukaemia; Precursor cell lymphoblastic leukaemia-lymphoma; Follicular lymphoma; Mantle-cell lymphoma; B-cell lymphoma
  • New Molecular Entity No

Highest Development Phases

  • Marketed B-cell lymphoma; Diffuse large B cell lymphoma; Follicular lymphoma
  • Preregistration Marginal zone B-cell lymphoma; Non-Hodgkin's lymphoma
  • Phase II Haematological malignancies; Solid tumours
  • No development reported Leukaemia

Most Recent Events

  • 09 Dec 2024 Efficacy and adverse event data from the phase II ZUMA-5 trial in Non-Hodgkin's lymphoma released byGilead Sciences
  • 07 Dec 2024 Updated efficacy, pharmacokinetic and adverse events data from a phase II ZUMA-5 trial in Non-Hodgkin's lymphoma presented at the 66th American Society of Hematology Annual Meeting and Exposition (ASH-2024)
  • 05 Dec 2024 Kite Pharma completes the phase-II ZUMA-5 trial in Follicular lymphoma, Non-Hodgkin's lymphoma, and Marginal zone lymphoma (Second-line therapy or greater)in France and USA (NCT03105336),

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