Axicabtagene ciloleucel - Kite Pharma

Drug Profile

Axicabtagene ciloleucel - Kite Pharma

Alternative Names: Axi-cel; KTE-C19; KTE-C19 CAR; Yescarta

Latest Information Update: 17 Jul 2018

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At a glance

  • Originator Cabaret Biotech
  • Developer Daiichi Sankyo Inc; Genentech; H. Lee Moffitt Cancer Center and Research Institute; Kite Pharma; National Cancer Institute (USA)
  • Class CAR-T cell therapies; Gene therapies; Immunotherapies
  • Mechanism of Action Immunologic cytotoxicity; T lymphocyte replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Diffuse large B cell lymphoma; Chronic lymphocytic leukaemia; Precursor cell lymphoblastic leukaemia-lymphoma; Mantle-cell lymphoma; Follicular lymphoma
  • New Molecular Entity No

Highest Development Phases

  • Marketed B cell lymphoma; Diffuse large B cell lymphoma
  • Preregistration Follicular lymphoma
  • Phase II Mantle-cell lymphoma; Non-Hodgkin's lymphoma
  • Phase I/II Precursor cell lymphoblastic leukaemia-lymphoma
  • Phase I Leukaemia

Most Recent Events

  • 29 Jun 2018 Committee for Medicinal Products for Human Use issued a positive opinion for axicabtagene ciloleucel for diffuse large B-cell lymphoma and primary mediastinal large B-cell lymphoma in European union
  • 04 Jun 2018 Updated new efficacy and safety data from the phase I/II ZUMA-3 trial in Acute lymphoblastic leukaemia released by Kite Pharma
  • 04 Jun 2018 Updated new efficacy data from the phase I/II ZUMA-1 trial for B-cell lymphoma released by Kite Pharma
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