Research programme: oral biotherapeutics - Intrexon

Drug Profile

Research programme: oral biotherapeutics - Intrexon

Alternative Names: AG015; Antibody-toxin conjugates - Intrexon; Clostridium difficile enteropathy therapeutic - Intrexon; Clostridium difficile-associated enterocolitis therapeutic - Intrexon; Coeliac Disease ActoBiotics™ - ActoGeniX; Coeliac disease therapeutics - Intrexon; IL-10/proinsulin ActoBiotics™; IL-27 - Intrexon; Inflammatory bowel disease ActoBiotics™; Inflammatory bowel disease therapeutics - Intrexon; Interleukin-27 - Intrexon; Lactococcus lactis expressing human interleukin-27; Lactococcus lactis secreting gluten antigens; Lactococcus lactis secreting human interleukin-27; Microbiome ActoBiotics™; Microbiome modulators - Intrexon; Microbiota ActoBiotics™; Microbiota modulators - Intrexon; Peptide-toxin conjugates - Intrexon; Proinsulin/IL-10 ActoBiotic™

Latest Information Update: 28 Feb 2018

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At a glance

  • Originator ActoGeniX
  • Developer Intrexon Corporation; Katholieke Universiteit Leuven; National Cancer Institute (USA); Synthetic Biologics
  • Class Antigens; Bacteria; Cytokines; Hormones; Monoclonal antibodies; Peptides; Recombinant proteins
  • Mechanism of Action Bacterial toxin inhibitors; Enzyme replacements; Helper-inducer T-lymphocyte modulators; Immunomodulators; Immunosuppressants; Interleukin 27 replacements; Microbiome modulators; Regulatory T-lymphocyte stimulants; Tumour necrosis factor alpha inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes - Coeliac disease; Type 1 diabetes mellitus

Highest Development Phases

  • Preclinical Type 1 diabetes mellitus; Type 2 diabetes mellitus
  • Research Digestive system disorders; Phenylketonuria
  • No development reported Coeliac disease; Inflammatory bowel diseases
  • Discontinued Clostridium-difficile-infections

Most Recent Events

  • 28 Feb 2018 No recent reports of development identified for preclinical development in Coeliac disease in USA (PO, Capsule)
  • 28 Feb 2018 No recent reports of development identified for preclinical development in Inflammatory-bowel-disease in Belgium (PO, Capsule)
  • 29 Jan 2018 Discontinued for Clostridium difficile infections in Belgium (PO)
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