Drug Profile
Acalabrutinib - Acerta Pharma/AstraZeneca
Alternative Names: Acalabrutinib maleate; ACP-196; CALQUENCE; CalquenceLatest Information Update: 17 Jan 2024
Price :
$50
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At a glance
- Originator Acerta Pharma
- Developer Acerta Pharma; AstraZeneca; Biologics Inc; National Institutes of Health (USA)
- Class Anti-infectives; Antineoplastics; Antirheumatics; Benzamides; Heavy metals; Imidazoles; Pyrazines; Pyridines; Pyrrolidines; Small molecules
- Mechanism of Action Agammaglobulinaemia tyrosine kinase inhibitors
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
Highest Development Phases
- Marketed Chronic lymphocytic leukaemia; Mantle-cell lymphoma
- Phase III Diffuse large B cell lymphoma
- Phase II B-cell lymphoma; Bladder cancer; Head and neck cancer; Non-Hodgkin's lymphoma; Non-small cell lung cancer; Ovarian cancer; Pancreatic cancer; Richter's syndrome; Waldenstrom's macroglobulinaemia
- Phase I/II B-cell prolymphocytic leukaemia; Follicular lymphoma; Glioblastoma; Multiple myeloma
- Phase I Infections
- Discontinued COVID 2019 infections; Haematological malignancies; Rheumatoid arthritis
Most Recent Events
- 13 Dec 2023 Phase-II clinical trials in Mantle-cell lymphoma (Combination therapy, First-line therapy) in United Kingdom (PO) (NCT05951959)
- 13 Dec 2023 AstraZeneca initiates enrolment in a phase II TrAVeRse trial for Mantle cell lymphoma (Combination therapy, First-line therapy) in Australia and United Kingdom (PO) (NCT05951959)
- 09 Dec 2023 Efficacy data from the phase II WAMM trial in Mantle-cell lymphoma presented at the 65th American Society of Hematology Annual Meeting and Exposition (ASH-Hem-2023)