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AMP 514

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Drug Profile

AMP 514

Alternative Names: AMP-514; MEDI-0680

Latest Information Update: 05 Nov 2023

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At a glance

  • Originator Amplimmune
  • Developer Amplimmune; AstraZeneca; MedImmune
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Programmed cell death 1 receptor antagonists; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II B-cell lymphoma
  • Discontinued Solid tumours

Most Recent Events

  • 17 Mar 2020 MedImmune completes a phase I/II trial in Solid tumours (Late-stage disease, Combination therapy) in USA, United Kingdom, Netherlands, France, Canada, Australia (IV) (NCT02118337)
  • 27 Sep 2019 Efficacy and adverse event data from a phase I/II trials in Solid tumours presented at the 44th European Society for Medical Oncology Congress (ESMO-2019)
  • 09 Feb 2018 Discontinued - Phase-I for Solid tumours (Late-stage disease) in USA (IV) before February 2018 (MedImmune pipeline, February 2018)

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