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Dordaviprone - Chimerix

Drug Profile

Dordaviprone - Chimerix

Alternative Names: NSC-350625; ONC 201; OP-10; TIC-10; TRAIL-inducing compound 10

Latest Information Update: 07 May 2024

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At a glance

  • Originator Oncoceutics
  • Developer Brown University; Case Comprehensive Cancer Center; Chimerix; Fox Chase Cancer Center; Kazia Therapeutics; Ohara Pharmaceutical; Oncoceutics; Rutgers; University of California at San Francisco; University of Texas M. D. Anderson Cancer Center
  • Class 3-ring heterocyclic compounds; Antineoplastics; Imidazoles; Pyridines; Pyrimidinones; Small molecules
  • Mechanism of Action Dopamine D2 receptor antagonists; Dopamine D3 receptor antagonists; Endopeptidase Clp stimulants; TNF-related apoptosis-inducing ligand receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glioma; Glioblastoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Glioma
  • Phase II Breast cancer; Endometrial cancer; Glioblastoma; Neuroendocrine tumours
  • Phase I/II Acute myeloid leukaemia; Colorectal cancer; Gallbladder cancer; Multiple myeloma; Myelodysplastic syndromes; Non-Hodgkin's lymphoma; Precursor cell lymphoblastic leukaemia-lymphoma
  • Phase I Cancer; Renal failure
  • Preclinical Adenocarcinoma; Liver cancer; Ovarian cancer; Prostate cancer; Sarcoma; Small cell lung cancer; Thyroid cancer
  • No development reported Mantle-cell lymphoma; Pancreatic cancer; Solid tumours

Most Recent Events

  • 01 May 2024 Chimerix plans to file regulatory application for Dordaviprone in Australia around year end
  • 01 May 2024 Chimerix plans to launch Dordaviprone in 2026
  • 16 Jan 2024 Fox Chase Cancer Center and Oncoceutics terminated a phase II trial for Endometrial cancer (Metastatic disease, Recurrent, Second-line therapy or greater) (PO)(NCT03099499)
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