Dordaviprone - Chimerix
Alternative Names: NSC-350625; ONC 201; OP-10; TIC-10; TRAIL-inducing compound 10Latest Information Update: 28 May 2024
At a glance
- Originator Oncoceutics
- Developer Brown University; Case Comprehensive Cancer Center; Chimerix; Fox Chase Cancer Center; Kazia Therapeutics; Ohara Pharmaceutical; Oncoceutics; Rutgers; University of California at San Francisco; University of Texas M. D. Anderson Cancer Center
- Class 3-ring heterocyclic compounds; Antineoplastics; Imidazoles; Pyridines; Pyrimidinones; Small molecules
- Mechanism of Action Dopamine D2 receptor antagonists; Dopamine D3 receptor antagonists; Endopeptidase Clp stimulants; TNF related apoptosis inducing ligand receptor agonists
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
Highest Development Phases
- Phase III Glioma
- Phase II Breast cancer; Endometrial cancer; Glioblastoma; Neuroendocrine tumours
- Phase I/II Acute myeloid leukaemia; Colorectal cancer; Gallbladder cancer; Multiple myeloma; Myelodysplastic syndromes; Non-Hodgkin's lymphoma; Precursor cell lymphoblastic leukaemia-lymphoma
- Phase I Cancer; Renal failure
- Preclinical Adenocarcinoma; Biliary cancer; Liver cancer; Ovarian cancer; Prostate cancer; Small cell lung cancer
- No development reported Mantle-cell lymphoma; Pancreatic cancer; Sarcoma; Solid tumours; Thyroid cancer
Most Recent Events
- 28 May 2024 No recent reports of development identified for preclinical development in Sarcoma in USA (PO)
- 28 May 2024 No recent reports of development identified for preclinical development in Thyroid-cancer in USA (PO)
- 01 May 2024 Chimerix plans to file regulatory application for Dordaviprone in Australia around year end