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Research programme: endostatin-derived peptide therapeutics - iBio

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Drug Profile

Research programme: endostatin-derived peptide therapeutics - iBio

Alternative Names: E4-Fc; Peptide E4

Latest Information Update: 17 Oct 2025

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At a glance

  • Originator Medical University of South Carolina
  • Developer iBio Inc
  • Class Angiostatic proteins; Peptides; Recombinant proteins; Skin disorder therapies
  • Mechanism of Action Angiogenesis inhibitors; Gelatinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes - Idiopathic pulmonary fibrosis; Systemic scleroderma

Highest Development Phases

  • Discontinued Solid tumours

Most Recent Events

  • 17 Oct 2025 Discontinued - Preclinical for Solid tumours in USA (Parenteral) (iBio pipeline, October 2025)
  • 28 Mar 2023 Preclinical trials in Solid tumours in USA (Parenteral) (iBio pipeline, March 2023)
  • 28 Mar 2023 Preclinical development is ongoing in USA for Solid tumours

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