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Zabilugene almadenorepvec - Synthetic Biologics

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Drug Profile

Zabilugene almadenorepvec - Synthetic Biologics

Alternative Names: VCN-01

Latest Information Update: 09 Sep 2025

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At a glance

  • Originator VCN Biosciences
  • Developer AstraZeneca; Theriva Biologics; VCN Biosciences
  • Class Antineoplastics; Eye disorder therapies; Gene therapies; Immunotherapies; Oncolytic viruses
  • Mechanism of Action Cell death stimulants; Hyaluronidase stimulants; Immunologic cytotoxicity
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Adenocarcinoma; Retinoblastoma
  • New Molecular Entity No

Highest Development Phases

  • Phase II Adenocarcinoma
  • Phase I/II Pancreatic cancer; Retinoblastoma; Squamous cell cancer
  • No development reported Brain cancer; Ovarian cancer; Solid tumours

Most Recent Events

  • 30 May 2025 Updated efficacy and adverse events data from a phase I trial in Retinoblastoma presented at the 61st Annual Meeting of the American Society of Clinical Oncology (ASCO-2025)
  • 14 May 2025 Theriva Biologics plans a phase III registrational trial for Adenocarcinoma (Pancreatic ductal adenocarcinoma) (Combination therapy)
  • 07 May 2025 Efficacy data from a phase II trial in Pancreatic cancer released by Theriva Biologics

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