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SIL 204

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Drug Profile

SIL 204

Alternative Names: KRASG12D-LODER; siG12D-LODER; SIL-204

Latest Information Update: 10 Sep 2025

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At a glance

  • Originator Silenseed
  • Developer Silexion Therapeutics
  • Class Antineoplastics; Small interfering RNA
  • Mechanism of Action KRAS protein expression inhibitors; RNA interference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Pancreatic cancer
  • Preclinical Colorectal cancer; Lung cancer

Most Recent Events

  • 04 Sep 2025 Silexion Therapeutics announces intention to submit the regulatory application to the European Union for the clinical trial of SIL 204 in Pancreatic cancer in the first quarter of 2026
  • 31 Jul 2025 Pharmacodynamics data from a preclinical trial in Cancer released by Silexion Therapeutics
  • 09 Jul 2025 Silexion Therapeutics plans a phase II/III trial for Pancreatic cancer (Late-stage disease, Adjunctive therapy) in the fourth quarter of 2026

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