Antisense K-ras RNA gene therapy - Silenseed

Drug Profile

Antisense K-ras RNA gene therapy - Silenseed

Alternative Names: KRASG12D-LODER; siG12D-LODER

Latest Information Update: 15 Feb 2018

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At a glance

  • Originator Silenseed
  • Class Antineoplastics; Gene therapies
  • Mechanism of Action KRAS protein modulators; Ras gene modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Phase II Pancreatic cancer

Most Recent Events

  • 06 Feb 2018 Phase-II clinical trials in Pancreatic cancer (Combination therapy, Late-stage disease, Inoperable/Unresectable) in USA (Intratumoural) (NCT01676259)
  • 11 Jan 2016 siG12D-LODER is in phase IIa development for Pancreatic cancer in Israel
  • 04 Jun 2013 Adverse events and efficacy data from a phase I/II trial in Pancreatic cancer presented at the 49th Annual Meeting of the American Society of Clinical Oncology (ASCO-2013)
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