Drug Profile

SIL 204

Alternative Names: KRASG12D-LODER; siG12D-LODER; SIL-204

Latest Information Update: 06 Jun 2025

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At a glance

Originator Silenseed
Developer Silexion Therapeutics
Class Antineoplastics; Small interfering RNA
Mechanism of Action KRAS protein expression inhibitors; RNA interference

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity No

Highest Development Phases

Phase II Pancreatic cancer
Preclinical Colorectal cancer; Lung cancer

Most Recent Events

29 May 2025 Pharmacodynamics data from a preclinical trial in Pancreatic cancer, Colorectal cancer, and Lung Cancer released by Silexion Therapeutics
21 May 2025 Preclinical trials in Colorectal cancer in Israel (Intratumoural), prior to May 2025
21 May 2025 Preclinical trials in Lung cancer in Israel (Parenteral), May 2025

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