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SIL 204

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Drug Profile

SIL 204

Alternative Names: KRASG12D-LODER; siG12D-LODER; SIL-204

Latest Information Update: 12 Jan 2026

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At a glance

  • Originator Silenseed
  • Developer Silexion Therapeutics
  • Class Antineoplastics; Small interfering RNA
  • Mechanism of Action KRAS protein expression inhibitors; RNA interference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Pancreatic cancer
  • Preclinical Colorectal cancer; Lung cancer

Most Recent Events

  • 06 Jan 2026 Silexion Therapeutics announces intention to submit IND submission for Pancreatic cancer in the second half of 2026
  • 16 Dec 2025 Silexion Therapeutics announces intention to submit regulatory application in the USA for Pancreatic Cancer
  • 02 Dec 2025 Silexion Therapeutics announced that it has received positive formal written Scientific Advice from the German Federal Institute for Drugs and Medical Devices (BfArM) regarding the proposed design of the planned phase II/III clinical trial for SIL204

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