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Tozuleristide - Blaze Bioscience

Drug Profile

Tozuleristide - Blaze Bioscience

Alternative Names: BLZ-100; Chlorotoxin conjugated to indocyanine green dye - Blaze Bioscience; Chlorotoxin-indocyanine-green-conjugate; CyTP-007; Tumor Paint BLZ-100; Tumour paint

Latest Information Update: 13 Dec 2023

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At a glance

  • Originator Blaze Bioscience
  • Developer Blaze Bioscience; Seattle Children's Hospital
  • Class Biological toxins; Drug conjugates; Imaging agents; Indoles; Peptides
  • Mechanism of Action Diagnostic imaging enhancers
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Brain cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III CNS cancer
  • Phase I/II Mouth neoplasm; Squamous cell cancer
  • Phase I Head and neck cancer
  • Preclinical Lung cancer
  • No development reported Breast cancer; Glioma; Skin cancer; Soft tissue sarcoma

Most Recent Events

  • 29 Nov 2023 University of Washington in collaboration with Blaze Bioscience reinitiates a phase I/II trial in Mouth neoplasm (Diagnosis) in USA (IV) (NCT05316688)
  • 31 Oct 2023 University of Washington in collaboration with Blaze Bioscience suspended phase I/II trial in Mouth neoplasm (Diagnosis) in USA (IV) due to staffing (NCT05316688)
  • 16 Oct 2023 Phase-I/II clinical trials in Mouth neoplasm (Diagnosis) in USA (IV) as of October 2023 (NCT05316688)
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