PU H71

Drug Profile

PU H71

Alternative Names: PU-H71; Purine-scaffold HSP90 inhibitor - Samus

Latest Information Update: 15 Jun 2018

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At a glance

  • Originator Memorial Sloan-Kettering Cancer Center
  • Developer Memorial Sloan-Kettering Cancer Center; National Cancer Institute (USA); Samus Therapeutics
  • Class Antineoplastics; Purines; Small molecules
  • Mechanism of Action HSP90 heat-shock protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Myelofibrosis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Breast cancer; Myelofibrosis; Pancreatic cancer
  • No development reported Lymphoma; Non-Hodgkin's lymphoma; Solid tumours

Most Recent Events

  • 13 Jun 2018 PU H71 receives Orphan Drug status for Myelofibrosis in USA
  • 14 Dec 2017 Phase-I clinical trials in Myelofibrosis (Combination therapy) in USA (IV) (NCT03373877)
  • 04 Nov 2017 No recent reports of development identified for phase-I development in Lymphoma(Late-stage disease) in USA (IV, Infusion)
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