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Obefazimod - Abivax

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Drug Profile

Obefazimod - Abivax

Alternative Names: ABX-464; SPL-464

Latest Information Update: 10 Oct 2024

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At a glance

  • Originator Splicos
  • Developer Abivax
  • Class Amines; Anti-inflammatories; Antirheumatics; Antivirals; Chlorobenzenes; Fluorobenzenes; Quinolines; Small molecules
  • Mechanism of Action MiRNA-124 expression stimulants; RNA cap-binding protein modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Ulcerative colitis
  • Phase II/III COVID 2019 infections
  • Phase II Crohn's disease; Rheumatoid arthritis
  • Preclinical Inflammatory bowel diseases
  • Discontinued HIV infections

Most Recent Events

  • 03 Oct 2024 Efficacy and safety data from a follow-up phase II trial in Ulcerative colitis released by Abivax
  • 03 Oct 2024 Phase-II clinical trials in Crohn's disease (Treatment-experienced) (PO) (NCT06456593)
  • 25 Sep 2024 Preclinical trials in Inflammatory bowel diseases in France (PO), before October 2024

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