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Obefazimod - Abivax

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Drug Profile

Obefazimod - Abivax

Alternative Names: ABX-464; SPL-464

Latest Information Update: 10 Mar 2026

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At a glance

  • Originator Splicos
  • Developer Abivax
  • Class Amines; Anti-inflammatories; Antirheumatics; Antivirals; Chlorobenzenes; Fluorobenzenes; Quinolines; Small molecules
  • Mechanism of Action MiRNA-124 expression stimulants; RNA cap-binding protein modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Ulcerative colitis
  • Phase II/III COVID 2019 infections
  • Phase II Crohn's disease; Rheumatoid arthritis
  • Preclinical Inflammatory bowel diseases
  • Discontinued HIV infections

Most Recent Events

  • 10 Mar 2026 Abivax plans phase I pharmacokinetics trial (In volunteers) in United Kingdom in March 2026 (PO) (NCT07453784)
  • 08 Oct 2025 Efficacy and adverse event data from the phase III ABTECT-2 trial in Ulcerative colitis released by Abivax
  • 06 Oct 2025 Pooled efficacy and adverse events data from phase III ABTECT 1 & 2 trials in Ulcerative colitis released by Abivax

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