Drug Profile

Futibatinib - Taiho Oncology/Taiho Pharmaceutical

Alternative Names: LYTGOBI; TAS 120

Latest Information Update: 10 Mar 2025

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At a glance

Originator Taiho Pharmaceutical
Developer Taiho Oncology; Taiho Pharmaceutical
Class Amines; Antineoplastics; Ketones; Phenyl ethers; Pyrazoles; Pyrimidines; Pyrrolidines; Small molecules
Mechanism of Action Type 1 fibroblast growth factor receptor antagonists; Type 3 fibroblast growth factor receptor antagonists; Type 4 fibroblast growth factor receptor antagonists; Type-2 fibroblast growth factor receptor antagonists

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

Yes - Cholangiocarcinoma
New Molecular Entity Yes

Marketed Biliary cancer
Registered Cholangiocarcinoma
Phase II/III Cancer
Phase II Breast cancer; Gastric cancer; Lymphoid leukaemia; Myeloid leukaemia; Oesophageal cancer; Solid tumours; Urogenital cancer
Phase I/II Non-small cell lung cancer
Preclinical Rhabdomyosarcoma

11 Nov 2024 Taiho Oncology completes a phase II trial in Lymphoid leukaemia, Gastric cancer, Solid tumours, Myeloid leukaemia (In adults, Late-stage disease, Metastatic disease, Second-line therapy or greater) in Belgium, South Korea, Japan, Netherlands, USA, Portugal, Italy, France, Germany, Hong Kong, Singapore, Spain, Sweden, Turkey, United Kingdom (PO) (NCT04189445)
16 Sep 2024 Phase-II/III clinical trials in Cancer (Combination therapy, Late-stage disease, Metastatic disease) in USA (PO) (NCT06506955)
16 Sep 2024 Phase-II/III clinical trials in Cancer (Monotherapy, Late-stage disease, Metastatic disease) in USA (PO) (NCT06506955)

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