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Seltorexant - Janssen Research & Development/Minerva Neurosciences

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Drug Profile

Seltorexant - Janssen Research & Development/Minerva Neurosciences

Alternative Names: JNJ-42847922; JNJ-7922; MIN-202

Latest Information Update: 14 May 2026

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At a glance

  • Originator Janssen Research & Development
  • Developer Janssen Research & Development; Minerva Neurosciences
  • Class Antidepressants; Fluorinated hydrocarbons; Ketones; Pyrimidines; Pyrroles; Sleep disorder therapies; Small molecules; Triazoles
  • Mechanism of Action Orexin receptor type 2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Major depressive disorder
  • Phase II Alzheimer's disease; Insomnia
  • No development reported Sleep apnoea syndrome

Most Recent Events

  • 30 Apr 2026 Janssen Research & Development initiates enrolment in a phase III trial for Major depressive disorder (Treatment experienced) in the US (PO) (NCT07573176)
  • 28 May 2025 Efficacy and adverse events data from a phase I trial in Healthy volunteers presented at the 126th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT-2025)
  • 28 Nov 2024 No recent reports of development identified for phase-I development in Major depressive disorder(Adjunctive treatment, In adolescents, In children, Treatment-experienced) in United Kingdom (PO, Tablet)

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