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Belantamab mafodotin - GSK

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Drug Profile

Belantamab mafodotin - GSK

Alternative Names: anti-BCMA-ADC - GSK ; Belamaf; belantamab mafodotin-blmf; blenrep; BLENREP; GSK'916; GSK-2857916; J6M0-mcMMAF

Latest Information Update: 22 Dec 2025

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At a glance

  • Originator GlaxoSmithKline
  • Developer Amgen; Atrium Health; GSK
  • Class Antineoplastics; Auristatins; Drug conjugates; Immunotoxins; Monoclonal antibodies
  • Mechanism of Action Apoptosis stimulants; Mitosis inhibitors; Tubulin polymerisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Multiple myeloma
  • New Molecular Entity Yes

Highest Development Phases

  • Registered Multiple myeloma

Most Recent Events

  • 16 Dec 2025 GSK and PrECOG plan the phase III PrE1005 trial for Multiple myeloma (Combination therapy, First-line therapy, Newly diagnosed) (IV), in May 2026 (NCT07285239)
  • 06 Dec 2025 Updated efficacy and adverse event data from the phase III DREAMM-8 trial in Multiple myeloma presented at the 67th American Society of Hematology Annual Meeting and Exposition (ASH-HEM-2025)
  • 06 Dec 2025 Updated efficacy data from the phase III DREAMM-7 trial in Multiple myeloma presented at the 67th American Society of Hematology Annual Meeting and Exposition (ASH-HEM-2025)

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