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Belantamab mafodotin - GSK

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Drug Profile

Belantamab mafodotin - GSK

Alternative Names: anti-BCMA-ADC - GSK ; Belamaf; belantamab mafodotin-blmf; blenrep; BLENREP; GSK'916; GSK-2857916; J6M0-mcMMAF

Latest Information Update: 06 Oct 2025

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At a glance

  • Originator GlaxoSmithKline
  • Developer Amgen; Atrium Health; GSK
  • Class Antineoplastics; Auristatins; Drug conjugates; Immunotoxins; Monoclonal antibodies
  • Mechanism of Action Apoptosis stimulants; Mitosis inhibitors; Tubulin polymerisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Multiple myeloma
  • New Molecular Entity Yes

Highest Development Phases

  • Registered Multiple myeloma
  • Phase II Plasmablastic lymphoma

Most Recent Events

  • 26 Aug 2025 Phase-III clinical trials in Multiple myeloma (Combination therapy, First-line therapy) in Germany (IV) (NCT06679101)
  • 05 Aug 2025 Phase-III clinical trials in Multiple myeloma (Combination therapy, First-line therapy) in Ireland, Greece, Czech Republic, Belgium, France, Italy, United Kingdom , USA (IV) (NCT06679101)
  • 23 Jul 2025 Registered for Multiple myeloma (Second-line therapy or greater, Combination therapy) in Canada (IV)

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