Belantamab mafodotin - GSK
Alternative Names: anti-BCMA-ADC - GSK ; Belamaf; belantamab mafodotin-blmf; blenrep; BLENREP; GSK'916; GSK-2857916; J6M0-mcMMAFLatest Information Update: 26 Nov 2025
At a glance
- Originator GlaxoSmithKline
- Developer Amgen; Atrium Health; GSK
- Class Antineoplastics; Auristatins; Drug conjugates; Immunotoxins; Monoclonal antibodies
- Mechanism of Action Apoptosis stimulants; Mitosis inhibitors; Tubulin polymerisation inhibitors
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Orphan Drug Status
Yes - Multiple myeloma
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
Highest Development Phases
- Registered Multiple myeloma
Most Recent Events
- 17 Nov 2025 Roswell Park Cancer Institute in collaboration with GlaxoSmithKline suspends a phase II trial for Multiple myeloma (Combination therapy, Second-line therapy or greater) in USA (IV) due to adverse events (NCT04876248)
- 12 Nov 2025 GlaxoSmithKline plans to initiate a phase II trial for Multiple Myeloma (In combination therapy, Second-line therapy or greater) (Parenteral) (NCT07227311)
- 05 Nov 2025 GlaxoSmithKline plans the phase II ALANIS trial for Amyloidosis (Combination therapy, Newly diagnosed) in December 2025 (NCT07224672)