Valiltramiprosate - Alzheon
Alternative Names: ALZ 801; BLU-8499; NRM-8499; Tramiprosate prodrug - AlzheonLatest Information Update: 10 Jul 2026
At a glance
- Originator BELLUS Health
- Developer Alzheon; BELLUS Health; National Institute on Aging
- Class Alkanesulfonic acids; Antidementias; Neuroprotectants; Propylamines; Small molecules
- Mechanism of Action Amyloid beta-peptide inhibitors
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Orphan Drug Status
No
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
Highest Development Phases
- Phase III Alzheimer's disease
- Discontinued Cerebral amyloid angiopathy; Down syndrome
Most Recent Events
- 25 Jun 2026 Alzheon terminates the APOLLOE4-LTE phase III long-term extension trial for Alzheimer's disease (Early-stage disease) in USA, Canada and United Kingdom (PO, Tablet) due to sponsor business decision (NCT06304883)
- 27 Jul 2025 Updated efficacy data from the phase III APOLLOE4 trial in Alzheimer's disease presented at the Alzheimer's Association International Conference 2025 (AAIC-2025)
- 27 Jul 2025 Updated adverse events data from the phase III APOLLOE4 trial in Alzheimer's disease presented at the Alzheimer's Association International Conference 2025 (AAIC-2025)