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Valiltramiprosate - Alzheon

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Drug Profile

Valiltramiprosate - Alzheon

Alternative Names: ALZ 801; BLU-8499; NRM-8499; Tramiprosate prodrug - Alzheon

Latest Information Update: 09 Dec 2025

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At a glance

  • Originator BELLUS Health
  • Developer Alzheon; BELLUS Health; National Institute on Aging
  • Class Alkanesulfonic acids; Antidementias; Neuroprotectants; Propylamines; Small molecules
  • Mechanism of Action Amyloid beta-protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Alzheimer's disease
  • Discontinued Cerebral amyloid angiopathy; Down syndrome

Most Recent Events

  • 27 Jul 2025 Updated efficacy data from the phase III APOLLOE4 trial in Alzheimer's disease presented at the Alzheimer's Association International Conference 2025 (AAIC-2025)
  • 27 Jul 2025 Updated adverse events data from the phase III APOLLOE4 trial in Alzheimer's disease presented at the Alzheimer's Association International Conference 2025 (AAIC-2025)
  • 27 Jul 2025 Efficacy data from a phase III APOLLOE4 trial in Alzheimer's disease presented at the Alzheimer's Association International Conference 2025 (AAIC-2025)

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