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Selonsertib - Gilead Sciences

Drug Profile

Selonsertib - Gilead Sciences

Alternative Names: ASK1 inhibitor - Gilead Sciences; GS-4977; GS-4997

Latest Information Update: 16 Aug 2023

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At a glance

  • Originator Gilead Sciences
  • Class Anti-inflammatories; Antihypertensives; Benzamides; Cardiovascular therapies; Imidazoles; Pyridines; Triazoles
  • Mechanism of Action MAP kinase kinase kinase 5 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Alcoholic hepatitis; Diabetic nephropathies; Kidney disorders; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Pulmonary arterial hypertension

Most Recent Events

  • 21 Jun 2023 Pharmacodynamics data from pooled analysis from two phase III trial in Non-alcoholic steatohepatitis presented at the European Association for the Study of the Liver Congress 2023 (EASL-2023)
  • 28 Apr 2022 Discontinued - Phase-II for Diabetic nephropathies in Canada, USA, New Zealand, Australia, Japan, United Kingdom, Italy, Spain (PO)
  • 03 Sep 2021 Gilead Sciences completes the phase II MOSAIC trial in Diabetic nephropathies in USA, Canada, New Zealand, Australia, Japan, Spain, Italy, and United Kingdom (PO) (NCT04026165)
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