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Vobramitamab duocarmazine - MacroGenics

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Drug Profile

Vobramitamab duocarmazine - MacroGenics

Alternative Names: Anti-B7-H3 antibody drug conjugate - MacroGenics; B7-H3; MGC 018

Latest Information Update: 07 Mar 2025

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At a glance

  • Originator MacroGenics
  • Class Antineoplastics; Cytostatic antibiotics; Drug conjugates; Immunoconjugates; Monoclonal antibodies
  • Mechanism of Action Alkylating agents
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Prostate cancer; Small cell lung cancer
  • Phase I Solid tumours
  • Preclinical Neuroblastoma

Most Recent Events

  • 23 Jan 2025 MacroGenics completes the phase II Tamarack trial in Prostate cancer (Hormone refractory, Metastatic disease, Second-line therapy or greater) in the US, Australia, Belgium, France, Italy, South Korea, Poland, Spain and the United Kingdom (NCT05551117)
  • 05 Nov 2024 MacroGenics paused a phase I trial in Solid tumours (Combination therapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (IV) (NCT05293496)
  • 13 Sep 2024 Updated adverse events and efficacy data from phase II Tamarack trial in Prostate cancer presented at the 49th European Society for Medical Oncology Congress (ESMO-2024)

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