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Vobramitamab duocarmazine - MacroGenics

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Drug Profile

Vobramitamab duocarmazine - MacroGenics

Alternative Names: Anti-B7-H3 antibody drug conjugate - MacroGenics; B7-H3; MGC 018

Latest Information Update: 22 Oct 2025

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At a glance

  • Originator MacroGenics
  • Class Antineoplastics; Cytostatic antibiotics; Drug conjugates; Immunoconjugates; Monoclonal antibodies
  • Mechanism of Action Alkylating agents
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Discontinued Neuroblastoma; Prostate cancer; Small cell lung cancer; Solid tumours

Most Recent Events

  • 26 Aug 2025 MacroGenics completes a phase-I trial in Solid tumours (Combination therapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (Parenteral) (NCT05293496)
  • 28 Apr 2025 No recent reports of development identified for phase-I development in Solid-tumours(Combination therapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (IV, Infusion)
  • 25 Apr 2025 Pharmacodynamic data from a preclinical trial in Solid tumors presented at the 116th Annual Meeting of the American Association for Cancer Research (AACR-2025)

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