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Lorecivivint - Samumed

Drug Profile

Lorecivivint - Samumed

Alternative Names: Adavivint; SM-04690

Latest Information Update: 12 Jul 2020

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At a glance

  • Originator Samumed
  • Class Anti-inflammatories; Antirheumatics; Imidazoles; Indazoles; Pyridines; Small molecules
  • Mechanism of Action Clk dual-specificity kinase inhibitors; DYRK kinase inhibitors; Wnt signalling pathway inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Osteoarthritis
  • Phase I Intervertebral disc degeneration

Most Recent Events

  • 03 Jun 2020 Pooled adverse events data from a phase I and 2 phase II trial in Osteoarthritis presented at the 21st Annual Congress of the European League Against Rheumatism (EULAR-2020)
  • 03 Jun 2020 Pharmacodynamics data from preclinical trials in Osteoarthritis presented at the 21st Annual Congress of the European League Against Rheumatism (EULAR-2020)
  • 26 May 2020 Samumed initiates a pivotal phase III STRIDES 1 trial for Osteoarthritis in USA (Intra-articular) in May 2020 (NCT04385303)
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