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Larotrectinib - Bayer/Loxo Oncology

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Drug Profile

Larotrectinib - Bayer/Loxo Oncology

Alternative Names: ARRY-470; BAY 2757556; Larotrectinib sulfate - Bayer/Loxo Oncology; LOXO 101; VITRAKVI

Latest Information Update: 05 Nov 2023

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At a glance

  • Originator Array BioPharma
  • Developer Bayer; Loxo Oncology; National Cancer Institute (USA)
  • Class Amides; Antineoplastics; Fluorobenzenes; Pyrazoles; Pyrimidines; Pyrrolidines; Small molecules; Tumour-agnostic therapies
  • Mechanism of Action TrkA receptor antagonists; TrkB receptor antagonists; TrkC receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Solid tumours; Soft tissue sarcoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Solid tumours
  • Phase II Histiocytosis; Non-Hodgkin's lymphoma
  • Phase I/II CNS cancer
  • No development reported Precursor cell lymphoblastic leukaemia-lymphoma

Most Recent Events

  • 20 Oct 2023 Updated pooled efficacy and adverse events data from a phase I trial, phase I/II SCOUT trial and the phase II NAVIGATE in Solid tumors presented at the 48th European Society for Medical Oncology Congress (ESMO-2023)
  • 28 Jun 2023 Updated efficacy and adverse events data from the phase II trial in NAVIGATE presented at the 25th World Congress on Gastrointestinal Cancer (WCGC-2023)
  • 02 Jun 2023 Updated pooled efficacy data from the phase II NAVIGATE, phase I/II SCOUT and a phase I trial in Solid tumour presented at the 59th Annual Meeting of the American Society of Clinical Oncology (ASCO-2023)
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