Drug Profile

Plastoquinonyl decyl triphenylphosphonium - Mitotech

Alternative Names: Plastomitin; SkQ-1; SkQ1 eye drops; SkQ1 pill; Visomitin

Latest Information Update: 28 Jan 2025

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At a glance

Originator Mitotech
Class Anti-inflammatories; Benzoquinones; Eye disorder therapies; Halogenated hydrocarbons; Hepatoprotectants; Obesity therapies; Organophosphorus compounds; Small molecules
Mechanism of Action Antioxidants; Electron transport chain complex protein modulators; Ferroptosis inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

Yes - Leber's hereditary optic atrophy
New Molecular Entity No
Available For Licensing Yes

Phase III Dry eyes
Phase II Leber's hereditary optic atrophy
Preclinical Non-alcoholic steatohepatitis; Obesity
No development reported Acute kidney injury; Barth syndrome; Dry age-related macular degeneration; Glaucoma; Inflammation; Multiple sclerosis; Neurodegenerative disorders; Uveitis; Wet age-related macular degeneration

28 Jan 2025 No recent reports of development identified for phase-I development in Dry age-related macular degeneration in Russia (Ophthalmic, Drops)
28 Jan 2025 No recent reports of development identified for phase-I development in Glaucoma in USA (Ophthalmic, Drops)
15 Nov 2024 Pharmacodynamics data from a preclinical study in Non-alcoholic steatohepatitis presented at the The Liver Meeting 2024: 75th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD-2024)

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