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Olorofim - F2G

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Drug Profile

Olorofim - F2G

Alternative Names: F-901318

Latest Information Update: 24 Oct 2023

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At a glance

  • Originator F2G
  • Class Antifungals; Piperazines; Pyrimidines; Pyrroles; Small molecules
  • Mechanism of Action Dihydroorotate dehydrogenase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Mycoses; Coccidioidomycosis; Invasive bronchopulmonary aspergillosis
  • New Molecular Entity Yes

Highest Development Phases

  • Preregistration Mycoses
  • Phase III Invasive bronchopulmonary aspergillosis
  • Phase II Coccidioidomycosis

Most Recent Events

  • 21 Oct 2023 Efficacy data from the phase II FORMULA-OLS trial in Mycoses released by F2G
  • 11 Oct 2023 Pharmacodynamics data from a preclinical trial in Mycoses presented at the IDWeek 2023 (IDW-2023)
  • 23 Jun 2023 Preclinical trials in Mycoses in United Kingdom (Inhalation) (F2G pipeline, June 2023)

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