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Efinopegdutide - Hanmi Pharmaceutical

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Drug Profile

Efinopegdutide - Hanmi Pharmaceutical

Alternative Names: GLP-1/glucagon-agonist; Glucagon-like-peptides/glucagon; Glucagon/GLP-1-agonist; HM-12525A; JNJ 5111; JNJ-64565111; LAPS GLP/GCG; LAPS-GCG/GLP-1; LAPS-GLP-1/GCG; LAPS-GLP/GCG agonist; LAPS-GLP/Glucagon; LAPS-OXM; MK-6024; Oxyntomodulin immunoglobulin conjugate

Latest Information Update: 23 Jan 2026

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At a glance

  • Originator Hanmi Pharmaceutical
  • Developer Hanmi Pharmaceutical; Janssen Pharmaceuticals; Merck & Co
  • Class Antihyperglycaemics; Gastrointestinal hormones; Glucagon-like peptides; Hepatoprotectants; Obesity therapies; Recombinant fusion proteins
  • Mechanism of Action Glucagon receptor agonists; Glucagon-like peptide-1 receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Liver cirrhosis; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis
  • Discontinued Obesity; Type 2 diabetes mellitus

Most Recent Events

  • 29 Dec 2025 Merck Sharp & Dohme completes a phase II trial in Non-alcoholic steatohepatitis (In adults, In the elderly) in The US, Austria, Belgium, Canada, Chile, China, Colombia, Czechia, France, Hong-Kong, Hungary, Israel, Italy, Japan, Mexico, Peru, Portugal, Puerto Rico, Singapore, South Korea, Spain, Switzerland, Taiwan, Thailand, Turkey and the United Kingdom (SC) (NCT05877547)
  • 27 Jun 2025 Merck Sharp & Dohme completed a phase-II trial in Non-alcoholic fatty liver disease in Puerto Rico and USA (SC) (NCT06482112)
  • 18 Feb 2025 Merck Sharp & Dohme completes a pharmacokinetic phase I trial (In volunteers) in USA (NCT06701305)

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