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PRN 1008

Drug Profile

PRN 1008

Alternative Names: PRN-1008

Latest Information Update: 21 Dec 2019

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At a glance

  • Originator Principia Biopharma
  • Class Anti-inflammatories; Nitriles; Piperazines; Piperidines; Pyrazoles; Pyrimidines; Skin disorder therapies; Small molecules
  • Mechanism of Action Agammaglobulinaemia tyrosine kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Idiopathic thrombocytopenic purpura; Pemphigus vulgaris
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Pemphigus vulgaris
  • Phase II Idiopathic thrombocytopenic purpura
  • No development reported Autoimmune disorders

Most Recent Events

  • 07 Dec 2019 Efficacy and adverse events data from a phase I/II trial in Immune Thrombocytopenic Purpura presented at the 61st Annual Meeting and Exposition of the American Society of Hematology (ASH-2019)
  • 15 Oct 2019 Preliminary efficacy and adverse events data from a phase II trial in Idiopathic thrombocytopenic purpura released by Principia Biopharma
  • 11 Oct 2019 Efficacy and safety data from a phase II Believe-PV trial in Pemphigus vulgaris released by Principia Biopharma
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