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Mavacamten - Bristol Myers Squibb

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Drug Profile

Mavacamten - Bristol Myers Squibb

Alternative Names: BMS-986427; Camzaios; CAMZYOS; Camzyos; HCM 1; MAVA-Bristol Myers Squibb/Myokardia; MYK 461; SAR-439152

Latest Information Update: 25 Apr 2025

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At a glance

  • Originator MyoKardia
  • Developer Bristol-Myers Squibb; LianBio; MyoKardia
  • Class Cardiovascular therapies; Ethylamines; Heart failure therapies; Pyrimidinones; Small molecules
  • Mechanism of Action Cardiac myosin inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hypertrophic cardiomyopathy
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Hypertrophic cardiomyopathy
  • Phase II Heart failure

Most Recent Events

  • 25 Apr 2025 The US FDA updates mavacamten label to reduce echocardiography monitoring requirements and contraindication
  • 14 Apr 2025 Efficacy and adverse event data from the phase III ODYSSEY-HCM trial of Hypertrophic cardiomyopathy released by Bristol Myers Squibb
  • 27 Mar 2025 Updated efficacy and adverse events data from phase III EXPLORER HCM trial in Hypertrophic cardiomyopathy released by Bristol Myers Squibb

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