Nitric oxide inhalation - INOpulse - Bellerophon Therapeutics

Drug Profile

Nitric oxide inhalation - INOpulse - Bellerophon Therapeutics

Alternative Names: Inhaled nitric oxide - Bellerophon; inhaled NO; iNO- Bellerophon; Nitric oxide-INOpulse

Latest Information Update: 12 Oct 2018

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At a glance

  • Originator Ikaria Holdings
  • Developer Bellerophon Therapeutics
  • Class Anti-inflammatories; Antiacnes; Antiandrogens; Antibacterials; Antifibrotics; Antifungals; Antihypertensives; Antivirals; Free radicals; Macromolecular substances; Nitrogen oxides; Non-opioid analgesics; Small molecules; Vasodilators
  • Mechanism of Action Androgen receptor antagonists; Angiogenesis inducing agents; Cell death stimulants; Guanylate cyclase stimulants; Nitric oxide donors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pulmonary arterial hypertension
  • New Molecular Entity No

Highest Development Phases

  • Phase III Pulmonary arterial hypertension
  • Phase II Pulmonary hypertension

Most Recent Events

  • 09 Oct 2018 Efficacy data from the phase III INOvation-1 trial in Pulmonary arterial hypertension released by Bellerophon Therapeutics
  • 09 Oct 2018 Bellerophon Therapeutics expands the phase IIb iNO-PF trial in USA
  • 10 Aug 2018 Bellerophon Therapeutics withdraws the phase III INOvation-RW study in Pulmonary arterial hypertension in Canada and USA, prior to enrolment (Inhalation) (NCT03602781)
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