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Research programme: SNA based therapeutics - Exicure

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Drug Profile

Research programme: SNA based therapeutics - Exicure

Alternative Names: SNA constructs - Exicure; SNA targeting IL17RA - Exicure; SNA targeting IL4RA - Exicure; SNA targeting SCN9A - Exicure; Spherical nucleic acid constructs - Exicure

Latest Information Update: 28 Mar 2023

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At a glance

  • Originator AuraSense Therapeutics
  • Developer Dermelix Biotherapeutics; Exicure
  • Class Anti-inflammatories; Antifibrotics; Antineoplastics; Antipsoriatics; Eye disorder therapies; Neuroprotectants; Nucleic acids; Skin disorder therapies
  • Mechanism of Action CLN3 protein expression modulators; Gene modulators; HD protein inhibitors; Immunomodulators; Immunosuppressants; Interleukin 1 beta modulators; Interleukin 4 receptor modulators; Nav1.7 voltage-gated sodium channel modulators; Survival of motor neuron 2 protein expression stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes - Neuropathic pain

Highest Development Phases

  • Suspended Angelman syndrome; CNS disorders; Crohn's disease; Neuropathic pain; Ulcerative colitis
  • No development reported Eye disorders; Huntington's disease; Inflammatory bowel diseases; Netherton Syndrome; Respiration disorders; Spinal muscular atrophy
  • Discontinued Amyotrophic lateral sclerosis; Atopic dermatitis; Brain cancer; Epidermolysis bullosa; Fibrosis; Friedreich's ataxia; Lymphoma; Neuronal ceroid lipofuscinosis; Transplant rejection

Most Recent Events

  • 28 Mar 2023 No recent reports of development identified for research development in Netherton-Syndrome in USA
  • 14 Dec 2022 Exciure terminates collaboration agreement with Ipsen
  • 30 Sep 2022 Suspended - Preclinical for CNS disorders in USA (Intrathecal)

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