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Ziritaxestat - Gilead Sciences

Drug Profile

Ziritaxestat - Gilead Sciences

Alternative Names: G-451990; GLPG 1690

Latest Information Update: 15 Feb 2022

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At a glance

  • Originator Galapagos NV
  • Class Anti-inflammatories; Antifibrotics; Azetidines; Imidazoles; Nitriles; Piperazines; Pyridines; Small molecules; Thiazoles
  • Mechanism of Action ENPP2 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Idiopathic pulmonary fibrosis; Systemic scleroderma
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Chronic obstructive pulmonary disease; Idiopathic pulmonary fibrosis; Systemic scleroderma

Most Recent Events

  • 05 Sep 2021 Pharmacodynamics data from a preclinical trial in Idiopathic pulmonary fibrosis presented at the 31st Annual Congress of the European Respiratory Society (ERS-2021)
  • 25 Feb 2021 CTP Push 293466 - info was already covered from MR 9315594
  • 10 Feb 2021 Discontinued - Phase-I for Idiopathic pulmonary fibrosis (In volunteers) in Belgium (PO, capsule)
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