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Imifoplatin - Promontory Therapeutics

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Drug Profile

Imifoplatin - Promontory Therapeutics

Alternative Names: Phosphaplatin PT-112; PT-112

Latest Information Update: 16 Sep 2025

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At a glance

  • Originator Ohio University
  • Developer EMD Serono; National Cancer Institute (USA); National Cheng Kung University; Pfizer; Promontory Therapeutics; SciClone Pharmaceuticals
  • Class Antineoplastics; Cyclohexanes; Diamines; Phosphoric acid esters; Platinum complexes; Small molecules
  • Mechanism of Action Apoprotein stimulants; Apoptosis stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Multiple myeloma; Thymoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Malignant thymoma; Non-small cell lung cancer; Prostate cancer; Thymic epithelial tumour; Thymoma
  • Phase I/II Liver cancer; Solid tumours
  • No development reported Multiple myeloma

Most Recent Events

  • 30 May 2025 Updated pharmacodynamics, efficacy and adverse events data from a phase I/II clinical trial in Prostate cancer presented at the 61st Annual Meeting of the American Society of Clinical Oncology (ASCO-2025)
  • 20 May 2025 Promontory completed in person end of phase II (EOP2) meeting with the USFDA on phase III registrational study design
  • 20 May 2025 Promontary Therapeutics plans a phase III trial for Prostate cancer (Hormone refractory, Metastatic, Monotheray) (IV)

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