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Diroleuton - DS Biopharma

Drug Profile

Diroleuton - DS Biopharma

Alternative Names: 8,11,14-eicosatrienoic-acid; all-cis-8,11,14-eicosatrienoic-acid; Bishomo-gamma-linolenic acid; DGLA; DHLA; Dihomogammalinolenic-acid; DS 107E; DS-107G; DS-107J; DS107; Gamma-homolinolenic-acid; Homo-gamma-linolenic-acid; RO-12-1989

Latest Information Update: 16 Oct 2019

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At a glance

  • Originator Dignity Sciences
  • Developer DS Biopharma
  • Class Anti-inflammatories; Antiacnes; Antipruritics; Eicosanoids; Omega-6 fatty acids; Skin disorder therapies; Small molecules
  • Mechanism of Action CD40 antigen inhibitors; Interleukin 10 inhibitors; Tumour necrosis factor alpha inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Acne vulgaris; Atopic dermatitis; Pruritus
  • No development reported Radiation-induced skin damage; Wounds

Most Recent Events

  • 25 Jul 2019 Phase-II clinical trials in Atopic dermatitis in Latvia (PO) (EudraCT2019-000932-25) (NCT03817190)
  • 28 Jan 2019 DS Biopharma plans a phase II trial for Atopic dermatitis in June 2019 (NCT03817190) (EudraCT2019-000932-25)
  • 04 Jan 2019 Chemical structure information added
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