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Lisocabtagene maraleucel - Juno Therapeutics

Drug Profile

Lisocabtagene maraleucel - Juno Therapeutics

Alternative Names: anti-CD19-EGFRt-4-1BB-zeta modified CAR CD8+ and CD4+ T lymphocyte therapy - Juno Therapeutics; anti-CD19/EGFRt/4-1BB/zeta modified CAR CD8+ and CD4+ T lymphocyte therapy - Juno Therapeutics; EGFRt-4-1BB-modified-CAR-CD8+-and-CD4+-T-lymphocytes-Juno-Therapeutics; Gene modified autologous T cells; JCAR 017; Liso-cel

Latest Information Update: 20 Dec 2019

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At a glance

  • Originator Juno Therapeutics
  • Developer Celgene Corporation; Juno Therapeutics; Seattle Children's Hospital
  • Class CAR-T cell therapies; Gene therapies; Immunotherapies
  • Mechanism of Action Immunologic cytotoxicity; T lymphocyte replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Diffuse large B cell lymphoma; Chronic lymphocytic leukaemia; Precursor cell lymphoblastic leukaemia-lymphoma
  • New Molecular Entity No

Highest Development Phases

  • Preregistration Diffuse large B cell lymphoma
  • Phase III Non-Hodgkin's lymphoma
  • Phase II Chronic lymphocytic leukaemia; Leukaemia
  • Phase I/II Follicular lymphoma; Precursor B-cell lymphoblastic leukaemia-lymphoma

Most Recent Events

  • 19 Dec 2019 Preregistration for Diffuse large B cell lymphoma (Combination therapy, Second-line therapy or greater) in USA (IV)
  • 09 Dec 2019 Efficacy and safety data the phase I/II TRANSCEND CLL 004 in Chronic lymphocytic leukaemia released by Bristol-Myers Squibb
  • 09 Dec 2019 Updated efficacy and adverse events data from the phase II TRANSCENDWORLD PILOT trial in Non-Hodgkin's lymphoma released by Bristol-Myers Squibb
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