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Zanubrutinib - BeiGene

Drug Profile

Zanubrutinib - BeiGene

Alternative Names: BGB-3111; BRUKINSA

Latest Information Update: 18 Dec 2019

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At a glance

  • Originator BeiGene
  • Class Amides; Antineoplastics; Phenyl ethers; Piperidines; Pyrazoles; Pyrimidines; Small molecules
  • Mechanism of Action Agammaglobulinaemia tyrosine kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Waldenstrom's macroglobulinaemia; Mantle-cell lymphoma; Chronic lymphocytic leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Mantle-cell lymphoma
  • Preregistration Chronic lymphocytic leukaemia
  • Phase III Waldenstrom's macroglobulinaemia
  • Phase II Diffuse large B cell lymphoma; Follicular lymphoma; Lymphoma
  • Phase I B-cell lymphoma

Most Recent Events

  • 16 Dec 2019 Updated efficacy and adverse event data from the phase III ASPEN trial in Waldenstrom's macroglobulinemia released by BieGene
  • 08 Dec 2019 Efficacy and safety data from a phase I/II trial in Chronic lymphocytic leukemia released by Beigene
  • 08 Dec 2019 Efficacy and safety data from a phase Ib trial in B-cell lymphoma released by Beigene
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