Donafenib

Drug Profile

Donafenib

Alternative Names: CM 4307

Latest Information Update: 01 Nov 2017

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At a glance

  • Originator Suzhou Zelgen Biopharmaceuticals
  • Class Antineoplastics
  • Mechanism of Action Raf kinase inhibitors; Receptor protein-tyrosine kinase antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Colorectal cancer
  • Phase II/III Hepatocellular carcinoma
  • Phase II Thyroid cancer
  • Phase I/II Gastric cancer; Oesophageal cancer
  • Phase I Nasopharyngeal cancer

Most Recent Events

  • 01 Dec 2016 Phase-III clinical trials in Colorectal cancer (Metastatic disease, Second-line therapy or greater) in China (PO) (NCT02870582)
  • 01 Sep 2016 Phase-II clinical trials in Thyroid cancer in China (PO) (NCT02870569)
  • 12 Aug 2016 Suzhou Zelgen Biopharmaceuticals plans a phase II trial in Thyroid cancer in China (NCT02870569)
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