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Trilaciclib - G1 Therapeutics

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Drug Profile

Trilaciclib - G1 Therapeutics

Alternative Names: COSELA; G1T 28; G1T28-1

Latest Information Update: 06 Jul 2026

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At a glance

  • Originator G1 Therapeutics
  • Developer Boehringer Ingelheim; G1 Therapeutics; Quantum Leap Healthcare Collaborative; Simcere Pharmaceutical Group
  • Class Amines; Antineoplastics; Aza compounds; Chemoprotectants; Cyclohexanes; Ketones; Piperazines; Pyrazines; Pyridines; Pyrimidines; Pyrroles; Radioprotectives; Small molecules; Spiro compounds
  • Mechanism of Action Cyclin-dependent kinase 4 inhibitors; Cyclin-dependent kinase 6 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Marketed Myelosuppression
  • Phase III Small cell lung cancer; Triple negative breast cancer
  • Phase II Bladder cancer; Breast cancer; Non-small cell lung cancer
  • No development reported Cancer
  • Discontinued Colorectal cancer

Most Recent Events

  • 30 Jun 2026 Pharmacosmos initiates a phase III trial for Myelosuppression (Chemotherapy-induced, Prevention) (IV, Infusion) in US (NCT07473128)
  • 16 Mar 2026 Pharmacosmos plans a phase III trial for Myelosuppression (Chemotherapy-induced; Prevention ) (IV, Infusion) in March 2026 (NCT07473128 )
  • 09 Feb 2026 Trilaciclib is still in phase III PRESERVE 2 trial in Triple-negative-breast-cancer (Combination therapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease) in France, USA, Australia, Bulgaria, China, France, Georgia, Moldova, Poland, Spain, Russia, Serbia and Ukraine (IV) (NCT04799249)

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