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Pafolacianine - On Target Laboratories

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Drug Profile

Pafolacianine - On Target Laboratories

Alternative Names: CYTALUX; Folate fluorescein isothiocyanate conjugate - On Target Laboratories; Folate receptor-alpha-targeted fluorescent agent - On Target Laboratories; Folate receptor-alpha-targeted imaging agent - On Target Laboratories; OTL-0038; OTL-38; pteroyl-L-tyrosine-S0456

Latest Information Update: 14 Aug 2023

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At a glance

  • Originator Endocyte; Purdue University
  • Developer Centre for Human Drug Research; Indiana University School of Medicine; Leiden University Medical Center; On Target Laboratories; Purdue University; University of Pennsylvania
  • Class Cyclohexenes; Fluoresceins; Haptens; Imaging agents; Indoles; Pteridines
  • Mechanism of Action Diagnostic imaging enhancers
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer
  • New Molecular Entity No

Highest Development Phases

  • Registered Non-small cell lung cancer; Ovarian cancer
  • Phase II Endometrial cancer; Endometriosis; Renal cell carcinoma
  • No development reported Pituitary cancer; Primary hyperparathyroidism; Triple negative breast cancer

Most Recent Events

  • 06 May 2023 On Target Laboratories, GlaxoSmithKline and VU University Medical Center plan the phase I STRATIFY trial for Rheumatoid arthritis and Inflammatory bowel disease (Treatment experienced, Diagnosis) in Netherlands (IV), in June 2023 (NCT03938701)
  • 27 Mar 2023 Efficacy and adverse events data from the phase III ELUCIDATE trial in Non-small cell lung cancer (Diagnosis) released by On Target Laboratories
  • 31 Dec 2022 The US FDA approves a supplemental New Drug Application for Lung cancer in USA

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