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Research programme: Nav1.7 voltage-gated sodium channel inhibitors - SiteOne Therapeutics

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Drug Profile

Research programme: Nav1.7 voltage-gated sodium channel inhibitors - SiteOne Therapeutics

Alternative Names: GTX analogues - SiteOne Therapeutics; Guanidinium toxin analogues - SiteOne Therapeutics; NaV1.7 inhibitors - SiteOne Therapeutics; Selective NaV1.7 channel blockers - SiteOne Therapeutics; Sodium ion channel 1.7 inhibitors - OneSite Therapeutics; ST Oral; ST SubQ; ST Topical; ST-2578

Latest Information Update: 10 Jun 2025

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At a glance

  • Originator Stanford University
  • Developer SiteOne Therapeutics
  • Class Analgesics; Small molecules
  • Mechanism of Action Nav1.7 voltage-gated sodium channel inhibitors; Positron-emission tomography enhancers
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Pain
  • Discontinued Cancer; Muscle hypertonia; Postoperative pain; Pruritus

Most Recent Events

  • 30 May 2025 Discontinued - Preclinical for Pain in USA (PO)
  • 30 May 2025 Discontinued - Preclinical for Postoperative pain in USA (IV)
  • 30 May 2025 Discontinued for Cancer (Diagnosis) in USA (PO)

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