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Islatravir - Merck Sharp & Dohme

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Drug Profile

Islatravir - Merck Sharp & Dohme

Alternative Names: 4-ethynyl-2-fluoro-2-deoxyadenosine; EFdA; MK-8519; MK-8591; MK-8591-eluting implant

Latest Information Update: 11 Dec 2025

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At a glance

  • Originator Yamasa Corporation
  • Developer Gilead Sciences; Merck Sharp & Dohme
  • Class Alkynes; Antiretrovirals; Fluorinated hydrocarbons; Purine nucleosides; Small molecules
  • Mechanism of Action Nucleoside reverse transcriptase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued HIV infections; HIV-1 infections; HIV-2 infections

Most Recent Events

  • 05 Dec 2025 Merck Sharp & Dohme plans a phase II/III trial for HIV-1 infections (Treatment-Naïve, Combination therapy) in January 2026 (PO) (NCT07266831)
  • 19 Oct 2025 Pharmacodynamics data from a preclinical trial in HIV-1 infections presented at the IDWeek-2025 (IDW-2025)
  • 08 Jul 2025 Merck & Co plans a clinical trials for HIV 1 infections (Combination therapy)

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