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Islatravir - Merck Sharp & Dohme

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Drug Profile

Islatravir - Merck Sharp & Dohme

Alternative Names: 4-ethynyl-2-fluoro-2-deoxyadenosine; EFdA; MK-8519; MK-8591; MK-8591-eluting implant

Latest Information Update: 09 Oct 2025

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At a glance

  • Originator Merck Sharp & Dohme
  • Developer Gilead Sciences; Merck Sharp & Dohme
  • Class Alkynes; Antiretrovirals; Fluorinated hydrocarbons; Purine nucleosides; Small molecules
  • Mechanism of Action Nucleoside reverse transcriptase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued HIV infections; HIV-1 infections; HIV-2 infections

Most Recent Events

  • 09 Mar 2025 Pharmacokinetics data from a pharmacokinetics trial in HIV-1 infections presented at the 32nd Conference on Retroviruses and Opportunistic Infections (CROI-2025)
  • 30 Jan 2025 Merck Sharp & Dohme Corp completes a phase II trial for HIV-1 Infection (Combination therapy) in France, Switzerland and USA (NCT04564547) (EudraCT2020-003071-18)
  • 25 Jul 2024 Discontinued - Phase-I for HIV infections (SC) , before July 2024 (Merck pipeline, July 2024)

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